Dietary Links to Alzheimer’s Disease

Epidemiological studies have not identified causal factors for Alzheimer’s disease as seen in a number of reviews [Heyman et al., 1984; Mortimer and Hutton, 1985; Rocca et al., 1986; Schoenberg, 1986; Broe et al., 1990; Beard et al., 1992; Breteler et al., 1992; White, 1992; Disterhoft et al., 1994; Katzman and Kawas, 1994; Prince et al., 1994; Keefover, 1996; van Duijn, 1996]. However, recently several orally ingested substances have been found to delay the onset or progression of AD: estrogen [Tang et al., 1996b]; non-steroidal antiinflammatory drugs (NSAIDs) [Stewart et al., 1997]; and vitamin E [Sano et al., 1997].